ADME Toxicology Testing Market 2024 – Market Size & Segments Analysis, Industry Trends, Manufacturers Analysis, Opportunities and Forecast 2030
Page: 215 | Report Code: LS240304 | Research Suite: Report (PDF) & Market Data (Excel)
The ADME toxicology testing used in pharmaceutical industry
by assessing the absorption, distribution, metabolism and excretion (ADME)
properties of drug compounds, by evaluating how drugs are absorbed into the
body, distributed throughout the tissues, metabolized by enzymes and eventually
eliminated, ADME testing helps researchers understand the pharmacokinetic
profile of drug candidates and predict their behavior in living organisms, this
proactive approach allows pharmaceutical companies to make informed decisions
about whether to advance a drug candidate to clinical trials or modify the
chemical structure to enhance safety and efficacy.
MARKET OVERVIEW
The global market for ADME toxicology testing market was valued at
USD 6.65 Billion in 2021 and has potential to show the growth of USD 17.71
Billion by 2030, at a CAGR of 11.5% during the forecast period of 2022-2030,
the ADME toxicology testing plays a crucial role in drug development by helping
pharmaceutical companies assess the safety and efficacy of new drug candidates
before they progress to clinical trials and eventual market release, which is
driving the market growth.
GROWTH DRIVERS
The growing demand for new pharmaceutical product to address
a wide range of medical applications drives the need for robust ADME toxicology
testing market. As pharmaceutical companies intensify their research and development
efforts to bring innovative drugs to market, the demand for comprehensive ADME
testing services continue to rise, there is an increasing focus on ensuring the
safety and efficacy of pharmaceutical products where it plays a crucial role in
identifying potential adverse effects in the stage of drug development process,
enabling companies to mitigate risks and optimize the therapeutic benefits of
their products. The increasing prevalence of chronic disease such as cancer,
cardiovascular disorders and neurological conditions fuels the demand for novel
therapeutics and more over regulatory requirements imposed by health
authorities such as FDA (Food and Drug Administration) and EMA (European
Medicines Agency), mandate thorough ADME toxicology testing market as part of the drug
approval process.
MARKET SEGMENTATION:
·
By Technology – Cell
culture, High throughput screening, Molecular Imaging and OMICS Technology
·
By Application –
Systematic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity and others
·
By Method Outlook -
Cellular Assay, Biochemical Assay, In-silica and Ex-vivo
·
By Region - North America,
Europe, Asia Pacific, the Middle East and Africa, and South America.
ADME Toxicology Testing Market by
Technology Segment Review:
Cell culture technology involves growing cells derived from
humans or animals in a controlled environment to mimic physiological
conditions, the techniques may involve 3D cell structure models and
organ-on-a-chip platforms enhancing the predictive accuracy and relevance of
ADME toxicology testing. High throughput screening allows for the rapid and
automated testing of large numbers of compounds to identify potential drug
candidates with desirable pharmacokinetic properties, it uses platforms like
robotics, automated liquid handling systems and advanced data analysis software
to screen compound against ADME parameters that are absorption, distribution,
metabolism and excretion. Molecular imaging technology involves visualizing
biological processes at the molecular levels using imaging techniques such as
positron emission tomography (PET), single-photon emission computed tomography
(SPECT) and magnetic resonance imaging (MRI), it allows researchers to track
the distribution and metabolism of radiolabeled compounds in living organisms
and providing insights into drug behavior and tissue localization. OMICS
technology encompasses various high-throughput analytical approaches, by
profiling changes in gene expression, protein abundance, metabolite levels and
lipid composition it analyses and provide insights into the biological effects
of drug candidates, facilitating informed decision-making in drug development.
ADME Toxicology Testing Market by
Application Segment Review:
ADME toxicology testing helps in assessing toxicity profiles
including systemic toxicity which assess the adverse effects of drugs or
chemical substances on the entire organisms and evaluates the potential risk
associated with systemic exposure to substances such as chronic toxicity or
organ damage, renal toxicity focuses on evaluating the impact of drugs on
kidney function including renal injury, impaired renal clearance and
nephrotoxicity. Hepatotoxicity involves measuring liver function markers,
assessing liver enzyme activity and examining histopathological alterations in
liver tissues and guiding the drug development to minimize the risk of liver
related adverse effects. Neurotoxicity aims to identify the potential
neurotoxic effects of compounds such as cognitive impairment and neurological dysfunction
and inform risk assessment and safety evaluation in drug development.
ADME Toxicology Testing Market by
Method Outlook Segment Review:
The cellular assays involve
screening capabilities with the utilization of cell lines, primary cells or
stem cells to study drug interactions, receptor binding, cytotoxicity and more.
The biochemical assays measure the enzymatic activity, metabolic pathways and
biomolecular interactions and provide valuable insights into the metabolic fate
of drugs and predict the likelihood of drug induced toxicity in humans.
In-silico methods computational modelling, bioinformatics and predictive
algorithms are involved to predict the absorption, distribution, metabolism and
excretion properties and toxicological outcomes of drugs and chemicals. Ex-vivo
uses the tissue slices from the living organisms to study drug metabolism and
provide valuable data on tissue specific drug effects.
ADME Toxicology Testing Market by
Regional Analysis:
American dominates the market driven by the presence of
robust research infrastructure and presence of United States Food and Drug
Administration (US FDA) that mandates rigorous testing as part of the drug
approval process. Europe is a prominent market fueled by extensive
pharmaceutical research and presence of regulatory body like European Union’s
REACH (Registration, Evaluation, Authorization and Restriction of Chemicals).
Asia Pacific exhibits rapid growth in the ADME toxicology testing market driven
by expanding pharmaceutical sectors and rising healthcare expenditure. The
Middle East and Africa has a great market potential because of the growing
healthcare infrastructure.
Key
Challenges:
The high cost associated with ADME toxicology testing
including equipment and its maintenance and skilled personnel is a major
challenge for the market. Variability in individual pharmacokinetic profiles
and complex drug interactions necessitate further research which leads to long
period of time.
Competitive
Landscape:
Companies leading in the market aims to enhance the testing
accuracy, efficiency and predictive capacity that can position them at the
forefront of the market. Companies investing in regulatory affairs and quality
assurance to adhere global regulatory requirements and following guidelines
like Good laboratory Practices (GLP).
Global Key
Players:
·
Thermo Fisher Scientific
·
Promega Corp.
·
Agilent Technologies
·
Curia Global
·
Dassault Systemes
·
Beckman Coulter
·
Catalent
·
Charles River Laboratories
·
LabCorp Drug Development
· Eurofins Scientific
Attributes |
Details |
Base Year |
2022 |
Trend Period |
2023 – 2030 |
Forecast Period |
2023 – 2030 |
Pages |
215 |
By technology |
Cell culture, High throughput
screening, Molecular Imaging and OMICS Technology |
By application |
Systematic Toxicity, Renal
Toxicity, Hepatotoxicity, Neurotoxicity and others |
By Method Outlook |
Cellular Assay, Biochemical Assay,
In-silica and Ex-vivo |
By region |
North America, Europe, Asia
Pacific, the Middle East and Africa, and South America |
Company Profiles |
Thermo Fisher Scientific, Promega
Corp., Agilent Technologies, Curia Global, Dassault Systemes, Beckman
Coulter, Catalent, Charles River Laboratories, LabCorp Drug Development, Eurofins
Scientific |
Edition |
1st edition |
Publication |
Feb 2024 |