ADME Toxicology Testing Market 2024 – Market Size & Segments Analysis, Industry Trends, Manufacturers Analysis, Opportunities and Forecast 2030

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The ADME toxicology testing used in pharmaceutical industry by assessing the absorption, distribution, metabolism and excretion (ADME) properties of drug compounds, by evaluating how drugs are absorbed into the body, distributed throughout the tissues, metabolized by enzymes and eventually eliminated, ADME testing helps researchers understand the pharmacokinetic profile of drug candidates and predict their behavior in living organisms, this proactive approach allows pharmaceutical companies to make informed decisions about whether to advance a drug candidate to clinical trials or modify the chemical structure to enhance safety and efficacy.

MARKET OVERVIEW

The global market for ADME toxicology testing market was valued at USD 6.65 Billion in 2021 and has potential to show the growth of USD 17.71 Billion by 2030, at a CAGR of 11.5% during the forecast period of 2022-2030, the ADME toxicology testing plays a crucial role in drug development by helping pharmaceutical companies assess the safety and efficacy of new drug candidates before they progress to clinical trials and eventual market release, which is driving the market growth.

GROWTH DRIVERS

The growing demand for new pharmaceutical product to address a wide range of medical applications drives the need for robust ADME toxicology testing market. As pharmaceutical companies intensify their research and development efforts to bring innovative drugs to market, the demand for comprehensive ADME testing services continue to rise, there is an increasing focus on ensuring the safety and efficacy of pharmaceutical products where it plays a crucial role in identifying potential adverse effects in the stage of drug development process, enabling companies to mitigate risks and optimize the therapeutic benefits of their products. The increasing prevalence of chronic disease such as cancer, cardiovascular disorders and neurological conditions fuels the demand for novel therapeutics and more over regulatory requirements imposed by health authorities such as FDA (Food and Drug Administration) and EMA (European Medicines Agency), mandate thorough ADME toxicology testing market as part of the drug approval process.

MARKET SEGMENTATION:

·         By Technology – Cell culture, High throughput screening, Molecular Imaging and OMICS Technology

·         By Application – Systematic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity and others

·         By Method Outlook - Cellular Assay, Biochemical Assay, In-silica and Ex-vivo

·         By Region - North America, Europe, Asia Pacific, the Middle East and Africa, and South America.

ADME Toxicology Testing Market by Technology Segment Review:

Cell culture technology involves growing cells derived from humans or animals in a controlled environment to mimic physiological conditions, the techniques may involve 3D cell structure models and organ-on-a-chip platforms enhancing the predictive accuracy and relevance of ADME toxicology testing. High throughput screening allows for the rapid and automated testing of large numbers of compounds to identify potential drug candidates with desirable pharmacokinetic properties, it uses platforms like robotics, automated liquid handling systems and advanced data analysis software to screen compound against ADME parameters that are absorption, distribution, metabolism and excretion. Molecular imaging technology involves visualizing biological processes at the molecular levels using imaging techniques such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), it allows researchers to track the distribution and metabolism of radiolabeled compounds in living organisms and providing insights into drug behavior and tissue localization. OMICS technology encompasses various high-throughput analytical approaches, by profiling changes in gene expression, protein abundance, metabolite levels and lipid composition it analyses and provide insights into the biological effects of drug candidates, facilitating informed decision-making in drug development.

ADME Toxicology Testing Market by Application Segment Review:

ADME toxicology testing helps in assessing toxicity profiles including systemic toxicity which assess the adverse effects of drugs or chemical substances on the entire organisms and evaluates the potential risk associated with systemic exposure to substances such as chronic toxicity or organ damage, renal toxicity focuses on evaluating the impact of drugs on kidney function including renal injury, impaired renal clearance and nephrotoxicity. Hepatotoxicity involves measuring liver function markers, assessing liver enzyme activity and examining histopathological alterations in liver tissues and guiding the drug development to minimize the risk of liver related adverse effects. Neurotoxicity aims to identify the potential neurotoxic effects of compounds such as cognitive impairment and neurological dysfunction and inform risk assessment and safety evaluation in drug development.

ADME Toxicology Testing Market by Method Outlook Segment Review:

The cellular assays involve screening capabilities with the utilization of cell lines, primary cells or stem cells to study drug interactions, receptor binding, cytotoxicity and more. The biochemical assays measure the enzymatic activity, metabolic pathways and biomolecular interactions and provide valuable insights into the metabolic fate of drugs and predict the likelihood of drug induced toxicity in humans. In-silico methods computational modelling, bioinformatics and predictive algorithms are involved to predict the absorption, distribution, metabolism and excretion properties and toxicological outcomes of drugs and chemicals. Ex-vivo uses the tissue slices from the living organisms to study drug metabolism and provide valuable data on tissue specific drug effects.

ADME Toxicology Testing Market by Regional Analysis:

American dominates the market driven by the presence of robust research infrastructure and presence of United States Food and Drug Administration (US FDA) that mandates rigorous testing as part of the drug approval process. Europe is a prominent market fueled by extensive pharmaceutical research and presence of regulatory body like European Union’s REACH (Registration, Evaluation, Authorization and Restriction of Chemicals). Asia Pacific exhibits rapid growth in the ADME toxicology testing market driven by expanding pharmaceutical sectors and rising healthcare expenditure. The Middle East and Africa has a great market potential because of the growing healthcare infrastructure.

Key Challenges:

The high cost associated with ADME toxicology testing including equipment and its maintenance and skilled personnel is a major challenge for the market. Variability in individual pharmacokinetic profiles and complex drug interactions necessitate further research which leads to long period of time.

Competitive Landscape:

Companies leading in the market aims to enhance the testing accuracy, efficiency and predictive capacity that can position them at the forefront of the market. Companies investing in regulatory affairs and quality assurance to adhere global regulatory requirements and following guidelines like Good laboratory Practices (GLP).

Global Key Players:

·         Thermo Fisher Scientific

·         Promega Corp.

·         Agilent Technologies

·         Curia Global

·         Dassault Systemes

·         Beckman Coulter

·         Catalent

·         Charles River Laboratories

·         LabCorp Drug Development

·         Eurofins Scientific

Attributes

Details

Base Year

2022

Trend Period

2023 – 2030

Forecast Period

2023 – 2030

Pages

215

By technology

Cell culture, High throughput screening, Molecular Imaging and OMICS Technology

By application

Systematic Toxicity, Renal Toxicity, Hepatotoxicity, Neurotoxicity and others

By Method Outlook

Cellular Assay, Biochemical Assay, In-silica and Ex-vivo

By region

North America, Europe, Asia Pacific, the Middle East and Africa, and South America

Company Profiles

Thermo Fisher Scientific, Promega Corp., Agilent Technologies, Curia Global, Dassault Systemes, Beckman Coulter, Catalent, Charles River Laboratories,

 LabCorp Drug Development, Eurofins Scientific

Edition

1st edition

Publication

Feb 2024

 


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