Single-Use Bioreactors Market 2022 - Market Size & Forecast, Industry Trends, Manufacturers Analysis, & Opportunities 2030

The global single-use bioreactors market is projected to witness growth at a CAGR of 23.0% during the forecast period 2022-2030.

Single-use bioreactors, also referred to as disposable bioreactors, employ disposable bags instead of reusable steel vessels to offer a custom environment for the growth and development of cells. These bioreactors are comparatively simpler, safer, flexible, and more environmentally friendlier. The range of applications of these bioreactors within pharmaceutical manufacturing is vast, including clinical trials, biofuel manufacturing, vaccine development, excipient research, and other related applications. These single-use bioreactors have become an essential part of the biotechnology manufacturing facilities and are therefore preferred over other traditional bioreactors.

GROWTH DRIVERS:

Factors such as the burgeoning acceptance and adoption of SUBs among small startups and companies across the globe; the growing fast-paced adoption and demand of single-use technologies in the pharmaceutical and biotechnology industry; the increasing awareness regarding the benefits of SUBs such as cost effectiveness, lower downtime and reduced energy and water consumption of single-use bioreactors; the growing government support for biopharmaceutical research; the increasing demand for biopharmaceuticals and the surging number of clinical trials coupled with the growing biopharmaceutical R&D across the world are primarily contributing towards the growth of the global single-use bioreactors market.

Additionally, it is estimated that the majority of the biopharmaceutical manufacturers in the industry employ 100% fully disposables facility in operation in the next few years as per the current fast pace adoption of single-use technology among the manufacturers. Sing-use bioreactors equipped with enhanced sensors and higher operational flexibility for multi-drug production within less time will be among the main equipment in these facilities. This is one of the prominent factors expected to fuel the growth of the global sing-use bioreactors market during the forecast period.

Moreover, the field of medical research has been garnering significant number of investments since the last few years. This has aided in the introduction of several technological advancements by the major companies in the industry. Some of the recent developments in bioreactors have been in the form enhanced designs, sensor systems, film technology, and stirring mechanism of the single-use bioreactors. These growing advancements in bioreactors are expected to significantly boost the market's growth in the upcoming years.

Furthermore, other factors such as the expanding biologics market, the increasing launch of new and innovative products, the soaring demand and number of commercially available personalized medicine, the growing advancements in molecular and cellular studies, the emergence of new applications of bioreactors in the pharma sector, the escalating number of vendors offering single-use bioreactors, the surging inclination of the industry toward using single‑use bioreactors, the augmenting relevance of molecular biology and notable developments in genetic modification are expected to further create ample growth opportunities for the global single-use bioreactors market.

However, regulatory concerns related to single-use bioreactors; extractability and leachability issues regarding disposable components like plastic bags used in bioreactors; issues regarding leaks; the high cost of disposables; and difficulties in meeting GMP standards are factors that may restrain the growth of the market up to certain extent during the forecast period.

SINGLE-USE BIOREACTORS MARKET SEGMENTATION:

By Product:

·         Single-use Bioreactor Systems

o   Up to 10L

o   11–100L

o   101–500L

o   501–1500L

o   Above 1500L

·         Single-use Media Bags

o   2D Bags

o   3D Bags

o   Other Bags

·         Single-use Filtration Assemblies

·         Other Products (Single-use vessels, tubing and connectors, samplers, and probes/sensor, and others)

 

By Type:

·         Stirred-tank SUBs

·         Wave-induced SUBs

·         Bubble-column SUBs

·         Other SUBs (Hybrid bioreactors and SUBs with vertically perforated discs)

 

By Type Of Cell:

·         Mammalian Cells

·         Bacterial Cells

·         Yeast Cells

·         Other Cells (Insect and plant cells)

 

By Molecule Type:

·         Monoclonal Antibodies

·         Vaccines

·         Gene-modified cells

·         Stem Cells

·         Other Molecules (Recombinant proteins including growth factors & interferons, antisense, RNA interference and others)

 

By Usage Type:

·         Lab-scale Production

·         Pilot-scale Production

·         Large-scale Production

 

By Application:

·         Research and Development (R&D)

·         Process Development

·         Bioproduction

By End User:

·         Pharmaceutical & Biopharmaceutical Companies

·         CROs & CMOs

·         Academic & Research Institutes

 

By Region:

·         North America

·         Europe

·         Asia Pacific

·         Latin America

·         Middle East and Africa

 

According to product, the single-use bioreactor systems segment accounted for the largest share in the global single-use bioreactors market in 2021. The segment is expected to maintain its position in the forecast period owing to the proliferating adoption of these systems in biopharma applications due to the numerous benefits offered by these systems.

 

According to type, the stirred-tank SUBs segment held the largest share in the global single-use bioreactors market in 2021. The segment is anticipated to continue with the trend during the forecast period because of the growing preference for stirred-tank SUBs in the cultivation of aerobic microbial cultures.

 

According to type of cell, the mammalian cells segment dominated the global single-use bioreactors market in 2021. The segment is predicted to continue dominating the market owing to the enhanced adoption of mammalian cells as a result of their highly mechanized metabolic machinery.

According to molecule type, the monoclonal antibodies segment led the global single-use bioreactors market in 2021. The segment is expected to further retain is dominance in the market over the forecast period. The propelling demand for SUBs in the manufacturing of mAbs is the predominant factor contributing to the growth of the segment.

 

According to application, the bioproduction segment held the commanding position in the global single-use bioreactors market in 2021. The segment is expected to further lead the market in the forecast period owing to the surging utilization of single-use bioreactors in biomanufacturing. Also, the escalating demand for SUBs in CMOs, the rising demand for breakthrough therapies, and the growing government funding is also aiding in the segment’s growth.

 

According to end user, the pharmaceutical and biopharmaceutical companies accounted for the largest global single-use bioreactors market share in 2021. The segment is projected to continue with the trend during the forecast period. The growth of the segment can be attributed to factors such as the growing production of biologics coupled with the rapidly burgeoning R&D activities in these pharmaceutical and biopharmaceutical companies.

 

According to usage, the lab-scale production segment led the global single-use bioreactors market in 2021 and is expected to continue doing the same over the forecast period. Lab-scale production is the most common setting in which single-use bioreactors are used owing to the uncomplex operation, relatively reduced sterilization requirements, and less chances of cross-contamination. This factor is contributing to the growth of this segment.

REGIONAL OUTLOOK:

The North American region dominated the global single-use bioreactors market in 2021, followed by Europe. The region is anticipated to further retain its dominance in the market over the forecast period on account of factors such as the growing investments by major players in expanding their manufacturing facilities in the region; the presence of well-established biopharmaceutical industry in the region; the escalating government’s support for new biologics in the region; the increasing number of strategic collaborations between industries and academic institutions for enhancing the R&D resources in the region and the surging number of commercial therapeutics and vaccine development in the region. The U.S. is the major contributor to the growth of the market in the region.

The Asia Pacific region is predicted to attain the highest CAGR and be the fastest growing regional market for single-use bioreactors during the forecast period. The growth of the market in the region can be attributed to the rapidly expanding biopharmaceutical industry, the growing investments by pharmaceutical and biotechnology companies, the increasing life science research, and the rising number of CROs and CMOs in the developing nations of the region. Countries such as India, China, and Japan are among the major contributors to the growth of the market in the region.

KEY COMPANIES IN SINGLE-USE BIOREACTORS MARKET:

·         Merck KGaA

·         Getinge AB

·         Eppendorf AG

·         CESCO Bioengineering

·         PBS Biotech Inc.

·         Distek Inc.

·         Able Corporation & Biott Corporation

·         Sartorius Stedim Biotech

·         Thermo Fisher Scientific

·         Danaher Corporation

·         G&G Technologies Inc.

·         Meissner Filtration Products Inc.

·         OmniBRx biotechnologies

·         New Horizon Biotechnology Inc.

·         GE Healthcare

·         Applikon Biotechnology B.V.

·         Solaris Biotechnology SRL

·         Cellexus Ltd.

·         CESCO Bioengineering Co. Ltd.

·         Parker-Hannifin Corporation

·         Other Players